LIM Kinase (LIMK) Inhibitor

8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, has anti-LIMK1 activity. 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide has inhibitory property on cell motility.

LIMK-IN-3 (Compound 33) is a LIMK2 inhibitor (IC₅₀: 1.2 nM). LIMK-IN-3 can be used for glaucoma research.

LIJTF500025, a chemical probe, is a potent and selective LIMK inhibitor, with pIC₅₀ values of 6.77 and 7.03 for LIMK1 and LIMK2, respectively, as determined by NanoBRET. LIJTF500025 can be used for the research of cancer.

Limk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

PAK4-IN-5 (Compound 12i) is a PAK4 inhibitor (IC₅₀: 7.68 nM for PAK4, 1872.01 nM for PAK1). PAK4-IN-5 binds to PAK4 stably via multiple interactions. PAK4-IN-5 inhibits the proliferation and the migratory potential of MDA-MB-231 cells by inhibiting the phosphorylation of PAK4 and LIMK1. PAK4-IN-5 arrests cell cycle in the G0/G1 phase, induces apoptosis and ROS production. LD₅₀: >500 mg/kg for mice (p.o.).

Limk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Limk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Limk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Limk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC₅₀ of 8 nM.

CPS-021 is a selective PAK4 PROTAC degrader with a DC₅₀ of 50 nM. CPS-021 degrades PAK4 via the ubiquitin-proteasome system. CPS-021 inhibits the migration and invasion of tumor cells, suppresses TGFβ-induced epithelial-mesenchymal transition (EMT) in tumor cells, and can be used in studies related to lung cancer metastasis.

Curcolonol is a furan type sesquiterpene. Curcolonol can be isolated from several medical herbs. Curcolonol has inhibitory activity for LIM kinase 1. Curcolonol can be used for the research of breast cancer.

LIMK2 Human Pre-designed siRNA Set A contains three designed siRNAs for LIMK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LIMK-IN-2 (Compound 52) is an LIMK inhibitor. LIMK-IN-2 can suppress the cell migration of osteosarcoma and cervical cancer cells, demonstrating potential anti-angiogenic activity.

LIMK1-IN-3 is a LIMK1 inhibitor with an IC₅₀ of 4.4 μM. LIMK1-IN-3 shows potential for use in cancer-related research.

Aurora/LIM kinase-IN-1 (Compound F114) is a potent and dual inhibitor of aurora and lim kinase. Aurora kinases and lim kinases are involved in neoplastic cell division and cell motility, respectively. Aurora/LIM kinase-IN-1 inhibits GBM proliferation and invasion. Aurora/LIM kinase-IN-1 is a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future agent development efforts for GBM, and potentially other cancers.

Limk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

LIMK1 Human Pre-designed siRNA Set A contains three designed siRNAs for LIMK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

S3 peptide is a multifunctional synthetic peptide that acts as a LIMK1 inhibitor with an IC₅₀ of 40 μg/mL. S3 peptide blocks cofilin phosphorylation and SDF-1α (HY-P4911)-induced T cell chemotaxis, and reduces viral particle production of HIV-1 and M-PMV. S3 peptide forms dimers via intermolecular disulfide bonds to bind and disrupt LPS micelles, exerting anti-Gram-negative bacterial activity. S3 peptide serves as a targeting moiety for NKA α1 and is used for the construction of PET tracers. S3 peptide is applicable to research related to HIV-1 infection, M-PMV infection, breast cancer, liver cancer and non-small cell lung cancer.

LIMK1 inhibitor 1 (compound 24) is a LIMK1 inhibitor. LIMK1 inhibitor 1 can be used in anti-cancer research.

CZh226 is a selective PAK4 inhibitor with an IC₅₀ of 0.0111 μM and a K_i of 0.009 μM. CZh226 functionally inhibits PAK4 activity and reduces the phosphorylation level of downstream signaling molecules. CZh226 inhibits the migration and invasion of tumor cells. CZh226 is applicable to lung cancer-related research.

LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC₅₀s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC₅₀ values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research.